الفهرس 
B[?]P toxicityOnly 14 pages are availabe for public view
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Abstract
Reishi mushroom (Ganoderma lucidum, family Ganodermaceae) is spread all over the world and is widely used for several nutritional and medical purposes. Therefore, knowledge of all aspects of the composition, toxicity and biological activities related to this mushroom is required. The present study aims to determine the bioactive compounds content, toxicity studies and antibacterial/antifungal activities of Ganoderma lucidum ethanol extract (GL-EE). Data of the nutrients composition of Ganoderma lucidum powder indicated that crude fiber and carbohydrates were the most largest compounds (51.06 ± 2.42 and 36.17 ± 3.91%, respectively) followed by total protein (8.69 ± 0.69 %), ash (2.21 ± 0.14%) and crude fat (1.87 ± 0.20%.). Also, Furthermore, nutraceuticals (bioactive compounds) content of GL-EE indicated that terpenoids were the most largest compound (241.47± 20.72 mg linalol.100 g-1) followed by polysaccharides (154.30± 19.06 mg starch equivalent.100 g-1), phenolics (49.98 ± 5.61 mg gallic acid equivalent.100g-1), triterpenoids (51.16 ± 6.49 mg ursolic acid.100 g-1).Furthermore, GL-EE recorded antibacterial and antifungal. On the other side, the toxicity studies of GL-EE was evaluated in Albino rats using standard methods. Various doses (2000 and 5000 mg/kg) of the extract were orally administered to rats and kept under close observation for the next 10 days. Data of the acute toxicity study did not show any toxicity sign and symptoms at doses, 2000 mg/kg and 5000 mg/kg, of GL-EE. Such signs and symptoms including no morbidity or mortality were observed. As a result, the LD50 of the Gl-EE could be greater than 5000mg/kg body weight. This implied the effective biotransformation and elimination of this natural product within a short time period. Therefore, the present study recommended like of that Ganoderma lucidum extract (GL-EE) could be used safety in different nutritional and medical applications.