الفهرس 
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Abstract
Rheumatoid arthritis is a systemic autoimmune pathology associated with a chronic inflammatory process, which can damage both joints and extra-articular organs, including the heart, kidney, lung, digestive system, eye, skin and nervous system. Kidney affection in RA is not uncommon and many pathologies can occur in the kidney as a complication of RA to identify these pathologies, many methods can be used such as renal biopsy, but biopsy is time consuming, costive, and many complications can occur as a result.so, we had to find alternative method to role in these pathologies, such as determination of urinary proteins which can tell us where is the pathology and which part of the kidney is affected. For example, if urinary albumin excretion is increased, this means that the pathology affect the glomeruli, but if other urinary proteins rather than albumin (NAP) are increased, this means that the site of pathology is the tubules. To identify the urinary proteins ,many methods can be followed: one of them is urinary protein electrophoresis another method is that we used in our study by measuring total urinary proteins (PCR) and measuring urinary albumin (ACR) then calculation of NAP by the following equation : NAP = PCR – ACR . Our cross sectional study was conducted on 100 subjects (20 control and 80 RA patients) all the patients and control were subjected to: A. Thorough history taking. B. Complete physical examination. C. Laboratory investigations including: • Fasting blood glucose. • Complete blood count. • Blood urea and serum creatinine. • eGFR • Liver function tests (ALT, AST, S.albumin). • Erythrocyte sedimentation rate (ESR). • C- reactive protein (CRP). • Rheumatoid factor (RF). • Anti-cyclic citrullinated peptide antibody (Anti-CCP). • Morning sample urine analysis. • Urinary Protein creatinine ratio (UPCR). • Urinary Albumin creatinine ratio (uACR). Non-albumin proteinuria will be calculated as follow: (urinary PCR -urinary ACR) The following results were obtained: • Proteinuria, non-albumin proteinuria had higher significant values in RA patients than control. • Albuminuria had higher but not significant values in RA patients than control. • Values of proteinuria, albuminuria and non-albumin proteinuria differs with disease activity grades. Conclusion: We can conclude that: in rheumatoid arthritis patients, there is a significant proteinuria mainly non albumin proteinuria more than albuminuria and this was noticed more in patients with active disease which may indicates a correlation between rheumatoid activity and tubulointerstial damage. Limitations: • Small size, single center study. • Number of patients not equal number of control and it is cross sectional study. Recommendations: • Further researches for more assessment of albuminuria and nonalbumin proteinuria in RA patients. • Further prospective, multi center studies which use large sample size (in which the number of patients equals the number of control) to role in if there is correlation between albuminuria, non-albumin proteinuria and disease activity.