الفهرس 
Evaluation of the effect of Metronidazole -loaded nanoparticles in the treatment of giardiasis in albino mice
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Abstract
Drug resistance to most antigiardial agents have raised in recent years. Standard treatment
for giardiasis is commonly with 5-nitroimidazol (5-NI) compounds, or metronidazole
(MDZ). We aimed to assess the antigiardial efficacy of low metronidazole dose loadedD.L-lactide-co-glycolide (LMD-PLGA) nanoparticles (NPs) and to compare it with the
standard high dose of metronidazole either free (HMD) or loaded on PLGA (HMDPLGA). PLGA NPs were prepared by single emulsification method, metronidazole (MTZ)
was loaded in low and high doses. The nanoparticles were evaluated in vivo for mice
model. Giardia lamblia infected mice were treated by LMD and HMD either free or PLGA
NPs loaded, the parasitic load and ployclonal antigiardial serum antibodies (IgG and IgA)
were reported. Histopathological studies on intestinal and liver sections were applied.
Results showed that PLGA NPs could be atrial delivery systems for antigiardial drugs to
improve their therapeutic efficacy and minimize their side effects that results from frequent
dosing