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Abstract The problem is further aggravated if these colonizing organismsare drug resistant with studies showing that neonates colonized withMRSA, VRE and ESBL producing Escherichia coli and Klebsiella have a higher chance of developing infections compared to those who are not colonized (Exner et al., 2017). The recent increase in multidrug-resistant bacteria (MDR) in healthcare settings is recognized as a global public health problem. Antimicrobial resistance, which has become natural phenomenon overtime, could be accelerated by the misuse of antibiotics in animals andhumans, leading to limited treatment options causing life-threatening infections increasing hospital costs (World Health Organization, 2018). Nosocomial infection and multiple drug resistant bacteria surveillance systems could be useful in the understanding of MDR epidemiology in children and neonates within a geographical region, as well as from a global perspective. It could also help in the recognition of prevalent pathogens based on the site of infection, optimization of resources, and stimulation of antibiotic rational used, while, contributing to multimodal strategies aimed at reducing MDR rates |