الفهرس | Only 14 pages are availabe for public view |
Abstract Abstract: The thesis is composed of an introduction and two original parts. In the first part, “N-carbamimidoyl4-((3-oxocyclohex-1-en-1-yl)amino)benzenesulfonamide” and “N-(4-(N-carbamimidoylsulfamoyl)phenyl)-2- cyanoacetamide” were used as precursors for the synthesis of a novel series of the respective 4-(2-amino-3- cyano-4-aryl-tetrahydroquinolin-1-yl)-N-carbamimidoylbenzenesulfonamide and 4-(6-amino-3,5-dicyano-2- oxo-4-arylpyridin-1-yl)-N-carbamimidoylbenzenesulfonamide derivatives. “In the second part, synthesis of some novel 9,10-diaryl-octahydroacridine-1,8-diones incorporating sulfamethoxazole was achieved through the reaction of cyclic enamine with incorporated sulfamethoxazole moiety with dimedone and aromatic aldehydes.” The work is extended to synthesize some heteroaryl substituted octahydroacridine-1,8-diones. The chemical constitution of all newly synthesized compounds are unambiguously verified based upon the different spectral tools and elemental analysis. |