الفهرس 
Title : Assessment ofanticancer effect of extra-virgin olive oil on oral squamous cell carcinoma cell lines : A non -randomized in vitro study
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Abstract
Oral squamous cell carcinoma has a remarkable incidence worldwide and a fairly onerous prognosis. The most obstacle in using anticancer drugs is their toxic effects on normal cells. Natural products. Recently, natural products grab the attention to be used in conjunction with anticancer drugs, one of them is extra virgin olive oil (EVOO).
Aim; this study aims to assess the effect of extra virgin olive oil on oral squamous cell carcinoma (OSCC) cell line order to be used as a complementary treatment modality.
Materials and methods: OSCC15 cell line was used in this study. It was divided into 3 groups 2 of which were exposed to EVOO and DOX separately while the 3rd one was left without any treatment. Then, cell viability, apoptosis, caspase 3 expression, cell cycle analysis and EGFR expression were assessed using flowcytometry and ELISA techniques
Results; EVOO showed anticancer effect but less DOX. It could reduce percentage of viable cells and EGFR, enhance apoptosis and increase the expression of caspase 3.
Conclusion; EVOO has a potential cytotoxic effect on OSCC cell line in dose-dependent manner. It can’t replace anticancer drugs but can be used as an adjuvant