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Abstract : Prematurity is the most common cause of under-five mortality globally, well above pneumonias, and malaria. Prematurity is classified into extremely preterm (<28 weeks), very preterm (between 28 and 32 weeks), moderate (between 32 and 34 weeks), and late preterm (34 to <37 weeks). Antenatal corticosteroid (ACS) considered one of the greatest success stories of modern obstetrics and neonatology. Objective: To study the effect of antenatal corticosteroids on respiratory morbidities in late preterm infants Study design: Case control study on late preterm infants conducted in Kasr Alainy obstetric department and neonatal ICU (NICU). The study included Case group (80 neonates late preterm infants (34-36+6 weeks) born at Kasr Alainy obstetric hospital with respiratory morbidities at birth and a Control group (80 neonates who are gestational age and sex matched healthy late preterm infants (34-36+6 weeks) born at Kasr Alainy obstetric hospital with no respiratory morbidity. Each group was divided into two subgroups according to administration of antenatal steroids. Results: There were highly statistically significant differences between the two studied groups regarding steroids use and steroid doses. There was no statistically significant difference in the occurrence of vaginitis, PROM, anemia, UTI between the two groups however, history of maternal hypertension was higher in the control group. There was no statistically significant difference between those who received steroids and those who did not in the occurrence of BPD, pneumothorax, sepsis or IVH. However NEC occurrence was statistically lower in those who received antenatal steroids |