الفهرس 
Fractional carbon dioxide laser versus intralesional methotrexate in treatment of keloids and hypertrophic scars A clinical and histopathological study
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Abstract
Background: Keloids and hypertrophic scars are prevalent skin disorders. Many treatment modalities have been used over the years with varying effectiveness including Intralesional corticosteroids injection Fractional CO2 laser and Intralesional methotrexate.
Aim of work: TO compare the efficacy and safety of Intralesional methotrexate and fractional CO2 laser therapy for the management of both keloids and hypertrophic scars clinically and histopathologically.
Methodology: Fifteen patients with keloids and hypertrophic scars were enrolled in the study. One lesion was treated via fractional CO 2, once every month for 4 months. The other lesion was treated with IL methotrexate injection, one session every 2weeks for 4 month Patients were assessed clinically and histopathologically before and after the last session by one month.
Result: VSS, Observer Scar Assessment Scale and PSOAS showed significant improvement following laser and methotrexate therapy. Collagen fibres showed significant improvement as regards appearance and pattern. When comparing the efficacy of laser and methotrexate, we found that the laser therapy led to more significant improvement than methotrexate therapy in VSS Observer Scar Assessment Scale, PSOAS and collagen fibers appearance and pattern. No significant correlation existed between clinical scores and histopathological parameters.
Conclusion: Fractional CO2 laser and Intralesional methotrexate are effective modalities for treatment of keloids and hypertrophic scars however fractional CO2 laser was superior to IL methotrexate as proved in our study