الفهرس 
List Of TablesOnly 14 pages are availabe for public view
 |  | from | 97 |  |  |
| | | from | 97 | | |
Abstract
Irritable bowel syndrome (IBS) is a worldwide functional gastrointestinal disease with a prevalence about 10% -15%. The main cause of irritable bowel syndrome is not definite.
Helicobacter pylori (H.Pylori) is a main cause of gastritis, peptic ulcer, gastric cancer, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Systemic inflammation caused by H. pylori can increase GIT mucosal permeability and modify gut flora. But, the exact relation between H. pylori infection and IBS incidence is still debated.
We aimed in this study to evaluate any possible relationship between irritable bowel syndrome occurrence and Helicobacter pylori infection.
In this prospective study, we recruited 95 patients referred to Sohag Tropical Hospital outpatient clinic from 1 April 2021 to 1 April 2022. All included patients were subjected to: a questionnaire: including sex, age and data on their symptoms, complete physical examination, H. pylori stool antigen and stool examination.
We categorized them into 2 groups: IBS patients (63.2%) and healthy individuals (36.8%) (as a control) according to Rome IV criteria. Most of the studied populations were females (56.8%) versus 43.2% males with a mean age of 38.26± 13.403 years.
IBS patients were significantly (P value= 0.001) younger than control group. Most IBS patients were females (60%) but with no significant difference over males.
The predominant presentation of the IBS in our cases was diarrhea 46.7%, followed by mixed diarrhea ad constipation (33.3%), then constipation (13.3%) and 6.7%can’t determine either they have constipation or diarrhea.
H. Pylori test was positive in 77.9% of them. H. pylori positive patients were significantly (P value= 0.001) older than negative group. We found that positive H. pylori test was more common in females (59.5%), but there was no significant difference in gender between the two groups,
We found that H. pylori test was positive in 45.4% of IBS patients with diarrhea followed by mixed type (36.4%) with lower prevalence in patients with constipation and unclassified type. But there is no significant difference in IBS types between H. pylori positive and negative groups.
H. pylori test was positive in 73.3% of IBS patients which was less than that in the control group (85.71%), but with no significant difference.
In conclusion, we found a high prevalence of H. pylori infection among the studied population. We found no significant association between IBS and H. pylori infection
Recommendations
We need larger samples to study the relationship between IBS and H. Pylori infection. We need also to study the role of H. pylori eradication therapy in improvement of IBS symptoms.