الفهرس 
Analytical study of some drugs affecting respiratory and cardiovascular systems
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Abstract
This thesis is concerned with the quantitative determination of some drugs affecting respiratory and cardiovascular systems. In this thesis, two mixtures were studied, separately, in their pharmaceutical formulations. The first mixture contains Amlodipine Besylate (AML) and Candesartan Cilexetil (CANC), while the second one contains Dyphylline (DPH) or Diprophylline (also known as Dihydroxypropyl theophylline), Ephedrine Hydrochloride (EPD) and Phenobarbital (PAB). The aim of this work was to develop different analytical methods that are characterized by simplicity, accuracy and appropriate degree of sensitivity for the analysis of the above-mentioned drugs in their pure forms, in their pharmaceutical formulations, biological fluids and in the presence of their degradation products and/or potential impurities.
High-performance liquid chromatographic (HPLC) and potentiometric ion selective electrodes methods were developed for the analysis of the first mixture (AML and CANC). The two cited drugs were investigated in their pharmaceutical formulations and in plasma together with their degradation products by developing high-performance liquid chromatographic methods coupled with UV diode array detection and fluorimetric detection. The principles of green chemistry and Quality-by-Design approach were successfully implemented throughout the developed HPLC-FD methods. Moreover, AML was electrochemically assayed by two different developed innovative ion selective electrodes (liquid-state ion selective electrode and solid-state ion selective electrode).
The second mixture (DPH, EPD and PAB) was assayed by two eco-friendly capillary electrophoretic and HPLC methods in their ternary mixture. In addition, two separate developed liquid state ion selective electrodes were designed for the assay of EPD and PAB in presence of their coformulated drug (DPH) in pharmaceutical formulation.
The principles of green chemistry were successfully implemented throughout the developed analytical methods and the greenness profile was assessed via several green metrics.