الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Breast cancer is the most frequently diagnosed life threatening cancer and the second most common cause of cancer death in women. Breast MRI is a highly sensitive imaging tool for breast cancer detection. It is used as a screening tool for women at high risk of developing breast cancer and pre-operative evaluation of extent of newly diagnosed breast cancer. Diffusion weighted imaging (DWI) in breast MRI is a useful sequence for many diagnostic applications and in developing novel imaging biomarkers. Dynamic contrast-enhanced MRI (DCE-MRI) has been established as a standard diagnostic technique incorporated into the Breast Imaging Reporting and Data System (BI-RADS). The higher specificity of quantitative DWI compared with DCE-MR alone for characterizing breast lesions has been demonstrated suggesting its potential as a biomarker to increase specificity and reduce false positives in the current diagnostic protocol in breast MRI.
The current study included 25 patients with 25 breast lesions. In our study we are aiming to improve the diagnostic performance of breast MRI so different combined MR methods including DWI have been studied and all with good results. In our study the sensitivity, specificity and PPV of DWI alone were (88.9%, 71.4% and 88.9% respectively). Using the combined protocol of morphological criteria including the T2WI and T2SPAIR signal intensity as well as DWI with ADC improve the sensitivity to 100 %, specificity to 85.7%, PPV increased to be 94.7%, NPV 100% and accuracy to 96%. Our results strongly suggest that combination of morphological criteria including the T2WI and T2SPAIR with DWI and ADC value will evidently increase the accuracy of diagnosis of breast lesions and improve the sensitivity and specificity for lesion characterization either benign or malignant.