الفهرس 
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Abstract
This prospective randomised trial was carried out on 60 elderly patients of both sexes from May 2021 to Aug 2022 at El Minia University Clinic following approval by the institutional ethical council of the faculty of medicine at Minia University (No. 55:2021). The clinical testing registry had the study listed. Thorough study (ID: NCT05442931 ). (ID: NCT05442931 ).
Pregabalin and magnesium sulphate were compared in this study’s evaluation of the effects of hypotensive anaesthesia during functional endoscobic surgical treatment.
Two equal groups of the study’s participants, each with 30 patients, were randomly assigned to participants:
group P: 100 ml of sterile saline and one 150 mg pregabalin tablet were administered 30 minutes prior to the onset of anaesthesia. IV
M group: 30 minutes prior to the onset of anaesthesia, 2 g of magnesium sulphate in 100 ml of saline was ingested.
All patients underwent evaluations based on the following criteria:
• Age, ethnicity, body weight, medical records, and lab tests are required prior to surgery (CBC,PC, PT ,INR )
• Intraoperative: Total amount of nitroglycerin used, hemodynamics, operating time, blood loss and transfusion, Fromme and Boezzart’s scale, and Likert scale.
• Hemodynamics, total nalpufin intake, hospital stay duration, pain score, relaxation score, Aldrete recuperation score, & lab tests are postoperative variables (CBC, PC, PT, INR).
The study’s findings showed no statistically significant differences among the two groups in terms of demographic information, hospital stay length, drowsiness score, et Aldrete recovery score.
When compared to the magnesium sulphate group, there was a significantly lower intraoperative total nitroglycerin intake in the pregabalin group.
The results also showed that the pregabalin group’s likert scale score was greater than the magnesium group’s, and that the pregabalin group’s Fromme & Boezaart scale score was significantly lower than that of the other group.
The blood transfusion between the two groups was equivalent, but there was a considerable reduction in internal bleeding with in prgabalin group compared to the magnesium group.
Additionally, there were notable differences in the two groups’ pain scores (visual analogue scores), with the pregabalin group’s vas score being lower than the magnesium group’s.
Therefore, using pregabalin during functional endoscopic surgical treatment can reduce overall intraoperative nitroglycerin intake, blood loss, length of hospital stay, and surgical field improvement in a safe and efficient manner that is superior to using magnesium sulphate.
Conclusion
Blood loss during surgery may be reduced, operational field vision can be enhanced, surgery time can be shortened, and fewer blood transfusions can be performed by using the method of controlled hypotensive anaesthesia. The surgical field and the surgeon’s experience during functional endoscopic surgical treatment are both enhanced by pregabalin’s ability to keep blood pressure under control.