الفهرس 
PROGESTERONEOnly 14 pages are availabe for public view
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Abstract
Background: It is believed that increased luteinizing hormone (LH) during the late follicular phase of the menstrual cycle causes increases in progesterone (P), and attempts have been made to use gonadotropin-releasing hormone as an agonist to prevent the rise in LH and subsequent premature luteinization. Administration of gonadotropin-releasing hormone agonist (GnRH-a) induces pituitary desensitization, and can effectively suppress the surge of early endogenous LH by (95-98%).
Aim of the Work: To investigate the relationship between the progesterone to estradiol (P/E2) ratio on the day of hCG administration and clinical pregnancy rates in patients with normal ovarian reserve undergoing GnRH agonist cycles.
Patients and Methods: After ethical committee approval and informed consent from the patients, this prospective cohort study was conducted at tertiary care hospital at IVF unit, Ain Shams University Maternity Hospital from August 2021 till September 2022 and performed on a total of 129 women attending IVF unit Ain Shams University hospital who were eligible for ICSI.
Results: As regards the cycle characteristics of the groups in patients with positive versus negative clinical pregnancy, there were no statistically significantly differences among the studied groups regarding duration of stimulation, number of follicles, endometrial thickness, LH, P/E2 ratio on trigger day, Number of retrieved oocytes, MII oocytes ( value< 0.05).
Conclusion: This study concluded that for patients undergoing standard long GnRH agonist protocol for ICSI cycles with a fresh embryo transfer and trigger-day serum P level of > 0.58 ng/mL, the P/E2 ratio does not seem to be an efficient parameter for predicting successful clinical pregnancy.