الفهرس 
PARKINSON’S DISEASEOnly 14 pages are availabe for public view
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Abstract
Background: Parkinson’s disease (PD) is the most common movement disorder, the 2nd most common neurodegenerative disorder after Alzheimer disease (AD). The hallmark neuropathology of PD is neuronal loss in the substantia nigra, which causes deficiency in striatal dopaminergic outflow, and accumulation of α-synuclein in intraneuronal inclusions.
Aim of the Work: To investigate the frequency of occurrence of GIT symptoms and their relation to patients’ characteristics in addition the characteristics of gut microbiota in PD patients in comparison to healthy controls and its relation to GIT symptoms.
Patients and Methods: This study is a case-control study, conducted at movement disorders clinic of neurology department at Ain Shams University Hospitals starting June 2022 till January 2023. People with PD from movement disorders clinic and healthy controls. 30 patients and 30 matched healthy controls.
Results: We did not observe significant differences in the relative abundance of the fecal microbiota in PD patients and controls. However, microbes associated with gut permeability and inflammation were found to be marginally altered in PD patients. Investigating larger populations could still turn up more statistically significant differences between PD subjects and controls, which cannot be fully ruled out.
Conclusion: Integrating microbiota outcomes with another layer of Omics (i.e., metabolomics) may broaden our knowledge on the influence of gut microbiota changes on the pathophysiology of the disease. Additionally, adopting highresolution techniques (i.e., shotgun) are necessary to identify biologically meaningful species or strains that might explain PD pathogenesis.