الفهرس 
Title : Gene Expression Analysis of Xanthine Oxidase in Induced Hyperuricemic Rats
AbstractOnly 14 pages are availabe for public view
 |  | from | 106 |  |  |
| | | from | 106 | | |
Abstract
The present study was conducted to investigate changes in expression of serum XO enzyme during
hyperuricemia and the ameliorating effect of natural safe source plants on the hyperuricemia in rats.
For this purpose, 50 male albino rats were categorized into 5 equal groups as follows:
(GI) Control group, (GII) Hyperuricemic group, (GIII) Febuxostat Hyperuricemic group, (GIV) G.
biloba hyperuricemic group, (GV) Onion juice hyperuricemic group. At the end of 4 weeks, blood
samples were collected and sera were separated and analyzed for determination of serum XO, ALT,
AST, ALP activities, UA , urea, creatinine and TP. conc. , liver and kidney specimens divided into
3 parts , Part for estimation of MDA, GSH, uric acid contents and SOD, GSH-Px activity , Part for
histopathological examination and Part (liver only) for studying XO gene expression
The obtained results were statistically analyzed and the general findings can be summarized as
follows:
PO caused hyperuricemia and increment in XO gene expression (slightly), serum XO, uric acid in
serum and tissue, urea and creatinine, caused various degrees of pathological damages in liver and
kidney.
Febuxostat decrease XO gene expression, serum XO, uric acid in serum and tissue, urea, creatinine,
both GBE and onion juice decrease XO gene expression (slightly), serum xo, UA in serum and
tissue, creatinine and relieved PO pathological changes in liver and kidney.
We conclusion, our findings suggested that the two studied plants (Gingko biloba and Onion) can
be considered as a source of natural antioxidants and xanthine oxidase inhibitors, that can be
developed, upon further investigation, into successful herbal drugs for therapeutic application
against gout and hyperuricemia