الفهرس 
LIVER TRANSPLANTATIONOnly 14 pages are availabe for public view
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Abstract
Background: Biliary complications are still frequent after liver transplantation especially living donor liver transplantation (LDLT). Bacterial cholangitis is a potentially life-threatening complication. Management is based on antimicrobial therapy and surgical drainage. Bile cultures can play a role in determining the causative agent and optimizing antibiotic therapy.
Aim: We aimed to assess the incidence of bacterial cholangitis among recipients of LDLL, identify the most common bacteria and their antibiotic susceptibility, and evaluate the role of bile culture and endoscopic retrograde cholangiopancreatography (ERCP) in the management of potential biliary infection.
Methods: This study was conducted at Ain Shams Center for Organ Transplantation between February 2019 and April 2022. The study included 39 LDLT recipients who developed post-transplant cholangitis on top of biliary complications. Liver function tests, imaging, ERCP, and blood and bile culture and sensitivity were performed in all patients.
Results: The incidence of biliary complications was 38.2%. Imaging and ERCP findings were consistent regarding the diagnosis of anastomotic stricture. Stones were detected by ERCP in 12 patients when magnetic resonance cholangiopancreatography detected them in only one patient. The most common organism isolated from both bile and blood cultures was E. coli. Antibiotics that matched bile and blood cultures were linezolid, ceftazidime/avibactam, imipenem + cilastatin, and amoxicillin/clavulanic acid. Three bile cultures showed multidrug resistance for combination therapy.
Conclusion: Anastomotic strictures and cholangitis are common complications of LDLT. E coli is the most common organism detected in bile and blood cultures. Therefore, antibiotic selection based on concurrent blood and bile culture interpretation can help optimize therapy.