الفهرس 
Analytical Study of Some Hydroxy Containing Drugs of Different Therapeutic Actions
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Abstract
This thesis involved analytical study of some drugs containing hydroxyl group and
described simultaneous analysis of binary and ternary mixtures by applying
chromatographic, spectrophotometric (univariate and multivariate), and electrochemical
methods.
The aim of work was to develop several simple, accurate, sensitive, selective and
precise methods for the assay of the studied drugs (prednisolone acetate, sulfacetamide
sodium, hydrocortisone acetate, and clioquinol) in their pure powdered form, laboratoryprepared mixtures and pharmaceutical formulation. The developed methods were applied
on topical preparations including Blephamide® eye drops and Vioderm Hydrocortisone®
Cream.
All the proposed methods were validated according to ICH guidelines and the
obtained results were statistically compared with those of the official and/or reported
methods using Student’s t-test, F-value and one-way ANOVA that showing no significant
difference with respect to accuracy and precision.
These methods could be used for the routine analysis of the studied drugs in quality
control laboratories with satisfactory accuracy and precision.