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Abstract
Background: Inherited thrombophilias have been reported to be associated with recurrent pregnancy loss (RPL), traditionally defined as three or more consecutive miscarriages occurring before 20 weeks post-menstruation. The aim of this study is to investigate the possible association between FVL, being the most common cause of inherited thrombophilias and the most common cause of activated protein C resistance (APCR), and RPL in the first trimester.Material and methods: Fifty patients with a diagnosis of unexplained recurrent first trimesteric pregnancy loss and fifty healthy control women having at least one child and with no history of RPL, were enrolled in this case control study. APCR was measured in all subjects, after exclusion of the most common known causes of RPL. The prevalence of APCR was compared between both groups. Results: Nine patients of the case group and four patients of the control group were proved to have abnormal APCR test with no statistically significant differences between both groups. Conclusion: FVL may increase the risk of first-trimester RPL however it is not an important independent cause. Routine FVL screening in first-trimester repeated abortion shouldn{u2019}t be the role