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Abstract
Vinpocetine is a CNS acting drug, it is used for treatment of many diseases like depression, Alzheimer and many cerebrovascular diseases. Vinpocetine has limited oral use due to its low water solubility, slow dissolution rate, poor absorption and significant first-pass metabolism that led to very low bioavailability. Additionally, it has very rapid elimination rate with short half- life that results in frequent drug dosing (three times daily), that increases side effects, toxicity and decreases patient compliance. The objective of this study was to enhance the bioavailability of Vinpocetine by developing new nanostructured formulae Finally, the nanostructured gels of oleic acid could be considered as promising nanocarriers for transmucosal and transdermal drug delivery of Vinpocetine