الفهرس Only 14 pages are availabe for public view
 |  | from | 176 |  |  |
| | | from | 176 | | |
Abstract
Background: Drug reactions are a major cause of patients{u2019} morbidity and account for a significant number of patients{u2019} deaths. So it is an utmost necessity for a dermatologist to have a comprehensive understanding of the clinical spectra of cutaneous adverse drug reactions(CADRs), as well as knowledge of the drugs which are frequently incriminated in such adverse reactions. Frequency of CADRs is variable with only few studies discussing it and with absent studies in Egypt. Aim of work:The aim of this study is to identify the clinical and pathological spectrum of CADRs and document the epidemiological data of different types of drug eruptions. Patients and methods:An observational hospital based analytical study was planned for a period of six months (January - June 2015). All patients attending the outpatient Dermatology Clinic at Kasr El Aini hospital during 6 days /week were examined to detect patients with CADRs.All patients who were diagnosed as CADRs were subjected to a detailed questionnaire regarding personal, present and past history and a detailed drug history. A skin biopsy was taken to confirm the diagnosis and to detect the type of CADRs. Results: The primary incidence of CADRs reported in our study is 0.28% (78 patients) from a total number of 27,093 patients.The most common CADRs are SJS/TEN in 12 patients (15.3%) and lichenoid drug eruptions in 12 patients (15.3%) followed by exanthematous drug eruptions in 11 patients (14.1%) and vasculitic drug eruptions in 9 patients (11.5%).The most common drug incriminated in all patients with CADRs is ibuprofen in 6 patients (7.6%) followed by penicillin in 4 patients (5.1%) and aspirin in 3 patients (3.8%). Comparing the duration of drug intake, duration between initiation of drug and onset of reaction and the duration of the eruption in severe CADRs versus other types of CADRs showed statistical significant difference with longer duration in other types of CADRs (P-value= 0.008, 0.040, 0.010 respectively)