الفهرس Only 14 pages are availabe for public view
 |  | from | 160 |  |  |
| | | from | 160 | | |
Abstract
Infectious complications are an important cause of morbidity and mortality in febrile neutropenic (FN) patients with hematological malignancies. To detect bacterial and fungal pathogens associated with infections in FN patients, assessing the current treatment protocol followed and determining outcome of febrile neutropenic episodes. The present study included 31 patients who experienced 65 FN episodes. All patients were subjected to full detailed history, complete physical examination, radiological investigations, complete blood picture, blood culture, other cultures according to the presenting symptoms and signs, galactomannan test for selected cases and PCR for sepsis screen for selected cases. Blood stream infections were diagnosed in 23.1% of episodes by either blood cultures or PCR. Other cultures were positive in 4.6% of episodes. Bacterial infections were detected alone in 15% of episodes; fungal infections alone in 14% of episodes, while both bacterial and fungal infections were detected in the same episode in 8% of episodes. Gram positive bacteria (57.9%) were more prevalent than gram negative bacteria (42.1%). CoNS were the most frequent microorganisms isolated. High resistance to ceftazidime was reported among gram-negative isolates. There was one proven fungal infection with Candida non-albican, 7 probable and 6 possible fungal infections. Mortality rate among patients was 7.7%. Blood culture is a very important tool to diagnose bacteremia in FN patients. CoNS are the most common microorganisms isolated from FN patients. Antibiotic susceptibility is essential to guide the treatment in FN patients