الفهرس Only 14 pages are availabe for public view
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Abstract
In a search for new anticancer candidates with improved profiles and selective properties and encouraged by the marked cytotoxic activity exhibited by some natural and synthetic furochromones and benzofurans against various malignant cell types, it deemed of interest to synthesize and investigate the potential anticancer and anti-VEGFR-2 activity of some new furochromone and benzofuran derivatives. Thus, in this study thirteen new furochromone derivatives and twenty three new benzofuran derivatives were synthesized through simple synthetic procedures. Some of the prepared known and all of the new furochromones and benzofurans were screened for their in vitro cytotoxicity and their in vitro and in vivo anti-VEGFR-2 activity. Furthermore, the tested compounds were investigated for their VEGFR binding properties through molecular docking studies. The thesis consists of the following parts: 1. Introduction: In this section, a brief literature review on the different classes of anticancer agents, VEGFR inhibitors and therapeutic strategies, different biological activities of furochromones and benzofurans, their anticancer activity and their anti-tyrosine kinases activity are presented. In addition, a survey on the natural sources as well as the different methods used for the synthesis of visnagin is also illustrated