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Abstract
The liver is the primary organ for drug metabolism and elimination for many antiepileptic drugs (AEDs). The hepatotoxicity induced by antiepileptic drug occurs either because of the production of reactive toxic metabolite(s) or because of induction of immuno-allergic reactions. The aim of this work was to investigate the protective and curative role of L-carnitine and baker yeast (Saccharomyces cerevisiae) against the effect of sodium valproate induced toxicity and oxidative stress in the liver. Materials and Method: Male albino rats (Rattus norvegious) were divided into: group I (Control): rats received distilled water orally by stomach gavage. group II (VPA): rats received VPA for six months. Protective main group which subdivided into (B-V), (L-V), (B-L-V) groups and treatment main group which subdivided into (V-B), (V-L), (V-B-L) groups: Physiological studies were investigated using liver function, lipid profile, oxidative stress and histopathological examination. Results: chronic administration of VPA for six months caused a significant increase in AST, ALT, ALP, bilirubin, total lipids, total cholesterol, LDL as well as oxidative stress; MDA and nitric oxide. While decreased total protein, albumin, globulin in addition to glutathione peroxidase and SOD. The administration of L-carnitine and baker yeast in the protective and treatment groups caused significant decreases in the activities of AST, ALT, bilirubin, lipid peroxidation and MDA levels and return the levels of total protein, albumin, globulin, glutathione peroxidase and SOD to the normal levels. In conclusion: L- carnitine and baker yeast (Saccharomyces cerevisiae) offer protection and curative effect to the liver by preserving the structural integrity of hepatocellular membrane against sodium valproate induced hepatotoxicity and oxidative stress