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Abstract
The aim of the work is to determine the role of peripheral o-opioid receptor to inhibit the excitability of rat DRG sensory neurons expressing EGFP (whose expression was driven by the Nav1.8 promoter region), following rat femoral artery occlusion for 72 hr which is a model likely similar to the blood flow condition in patient with chronic peripheral vascular disease. Then we aimed to determine the specific PTX-sensitive GÜ subunit that mediates the functional coupling of MOR and Ca²⁺ channels and also Ca²⁺ channels expressed in this identified DRG neurons which may help in better understanding of their role in mediating the EPR. This study may provide initial step for the development of novel drugs that selectively suppress the exaggerated exercise induced sympathetic reflex that exacerbates certain human diseases (e.g. peripheral arterial disease and chronic muscle ischemia) and to relive the exercise induced claudicating pain in peripheral vascular disease patients