الفهرس 
Studies on controlled-release oral delivery systems containing a slightly water soluble drug as a model drug
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Abstract
The goal of the drug delivery system is to provide a therapeutic concentration of drug to the proper site in the body resulting in therapeutic efficacy of the drug. The drug delivery system should deliver drug at a rate dictated by needs of the body over a specified period of time. Controlled release (CR) formulations have several potential advantages over immediate release (IR) formulations, such as providing a uniform and prolonged therapeutic effect, reducing the frequency of dosing, minimizing the side effects and reducing the strength of the required dose while increasing the effectiveness of the drug, thus improving patient compliance. Solid dispersions (SD) can be used to enhance the dissolution rate of poorly water soluble drugs and to sustain the drug release by choosing an appropriate carrier. Thus, a CR-SD comprises both functions of SD and CR for poorly water-soluble drugs. Such CR dosage forms containing SD provide an immediately available dose for an immediate action followed by a gradual and continuous release of subsequent doses to maintain the plasma concentration of poorly water- soluble drugs over an extended period of time