الفهرس 
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Abstract
Aim: This study aimed to evaluate the anesthetic efficacy of 4% Alexadricaine versus 2% Mepecaine-L for infiltration anesthesia in the extraction of maxillary first primary molars in children.
Methodology: The present study is a split-mouth study in which ten children aged from 5 to 7 years
with bilateral badly decayed maxillary first primary molars indicated for extraction were selected
from the outpatient diagnostic clinic in Pediatric Dentistry and Dental Public Health Department,
Faculty of Dentistry, Cairo University. The children’s teeth were randomly assigned to two groups.
group A received 4% Alexadricaine and group B received 2% mepecaine-L for infiltration
anesthesia. The intra-operative pain during the extraction was assessed using the Visual Analogue
Scale (VAS) and the Sound, Eyes and Motor Scale (SEM). Moreover, the onset and duration of soft
tissue anesthesia were objectively evaluated.
Results: group A showed slightly higher values of VAS and SEM scale than group B regarding
intra-operative pain during extraction with a statistically non-significant difference. Regarding the onset of soft tissue anesthesia, both groups had the same mean value (0.25±0.00). Regarding the
duration of soft tissue anesthesia, group A (214.00±9.66 minutes) showed a significantly higher
mean value than group B (162.50±16.87 minutes) with a statistically significant difference(P<0.001).
Conclusion: Regarding infiltration anesthesia in the extraction of maxillary first primary molars in
children, both 4% Alexadricaine and 2% Mepecaine-L can provide similar effective pain control
with rapid onset of action. However, 4% Alexadricaine has a longer duration of soft tissue numbness than 2% Mepecaine-L.