الفهرس 
Estimating the prevalence and predicting risk factors for developing chronic oral graft versus host disease in pediatric patients subjected to hematopoietic stem cells transplantation : Cross sectional study
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Abstract
Hemopoietic stem cells transplantation (HCT) using blood progenitor cells from the patient (autologous HCT) or a donor source (allogeneic HCT) has expanded to become an important component of the therapeutic armamentarium against several life-threatening cancers and non-malignant disorders Key developments in conditioning strategies (development of reduced-intensity and non-myeloablative conditioning), use of alternative donor source HCT (cord blood and haploidentical donors), emerging newer indications, and improvements in procedural technology and supportive care practices have safely expanded the applicability and utilization of HCTs.
Graft-versus-host disease (GVHD) is an important cause of morbidity and mortality in children receiving hematopoietic stem cell transplantation (HSCT).
GVHD is characterized by specific pathological and immunological manifestations, due to the transplantation of immunologically active T lymphocytes of a donor with a genome different from the recipient‟s into a compromised immune system.
cGVHD can affect many various organs, the oral cavity is the second most commonly involved organ system, behind skin involvement, with historically reported 45–83% prevalence among cGVHD patients.
Oral cGVHD can present as mucosal lesions, salivary gland dysfunction, and restricted mouth opening.
In a sample of Egyptian paediatric patients who underwent bone marrow transplantation, the prevalence of cGVHD is 68.08% , patients with oral cGVHD is 55.3%. No association was detected between oral manifestations and age, sex, transplant type, source of stem cells or occurrence of acute GVHD. Otherwise, association was significant between systemic and oral manifestations mainly skin, conditioning regimen and diminished salivary flow and between the trio oral manifestations where the combined lesions out of the total patients with oral cGVHD was 12 patients (46.1%).