الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Stroke is the leading cause of disability and the second most frequent cause of death worldwide . About 15 million people suffer stroke worldwide each year. Of these, 5 million die, and another 5 million are left permanently disabled .Acute ischemic stroke most commonly occurs when a blood vessel is obstructed by either thrombosis or embolism leading to irreversible brain injury and subsequent focal neurologic deficits.Serum biomarkers that predict the occurrence and outcome from ischemic stroke are critical for prevention and treatment. These biomarkers are considered to be the most valuable adjunct to routine clinical examination and imaging data . Fibrinogen is considered one of these biomarkers and act as a clotting factor that may accelerate the thrombotic process. Many cardiovascular and cerebrovascular disorders are accompanied by increased blood content of fibrinogen. Increased levels of fibrinogen result in changes in blood rheological properties such as increases in plasma viscosity, erythrocyte aggregation, platelet thrombogensis, alterations in vascular reactivity and compromises in endothelial layer integrity. These alterations exacerbate the complications in peripheral blood circulation during cardiovascular diseases such as hypertension, diabetes and stroke .