الفهرس 
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Abstract
An unsolved problem in global health is the antimicrobial resistance of Clinicallysignificant microorganisms. Recently, very drug-resistant microorganisms have emerged that are resistant to even the most potent antibiotics. This has caused a significant load on the healthcare system and a rise in morbidity and mortality rates globally. Antibiotic consumption is out of control and the pipeline for new antibiotic discoveries is drying up, raising warning bells that demand prompt action to stop this impending threat. Antibiotic resistance reversal and subsequent revival of the available antibiotic stockpile are some of the alternatives to the discovery of new antibiotics that are receiving interest. Antibiotic resistance reversal focuses primarily on the processes that increase an antibiotic’s ability to work effectively. These substances, which operate in concert with antibiotics, are known as resistance breakers or antibiotic adjuvants/potentiators. The identification of substances that lower the permeability barrier, express efflux pumps, and encode resistance-encoding enzymes has been the subject of numerous investigations.The stability, inheritance, and spread of the mobile genetic components connected to the resistance genes are potentially possible targets for drugs that aim to reduce antibiotic resistance. Numerous natural resources and synthetic substances have been used in the search for such chemicals. Many substances with intriguing properties are currently undergoing various stages of clinical testing. This review summarises all the research on using antibiotic potentiators to reverse antibiotic resistance and discusses what the future may hold for their application in clinical settings. Antibiotic have been essential in the fight against infection diseases caused by bacteria and other organisms for decades. Antimicrobial chemotherapy was a major factor in the twentieth century’s significant increase in average life expectancy. Disease-causing microorganisms that have developed resistant to antibiotic medication therapy, on the other hand, are becoming a growing public health concern. Antibiotics have become difficult to treat for wound infections, gonorrhea, Mycobacterium tuberculosis (TB), pneumonia, septicemia, and infant ear infections, to name a few. One aspect of the problem is that bacteria and other organisms that cause infections are other antimicrobial treatments. Another contributing factor is the increased use and misuse of existing antibiotics in human and veterinary care, as well as in agriculture. Antibiotic resistance is accelerated when antibiotics are underutilized, overused, or abused. Patients noncompliance with recommended treatment and demand, prescribers, irrational use of antibiotics in humans, drug advertising, dispensing doctors, and antibiotic use in agriculture, poor quality antibiotics, inadequate surveillance, and susceptibility testing all contribute to antibiotic resistance. To address a resistance problem, better antibiotic management is required, as well as the restoration of microorganisms receptive to these medications in the environment. Resistant bacteria would have no competition for survival if all reservoirs of vulnerable germs were removed, and they would live permanently.