الفهرس 
The Relationship Between Sleep Disorders And Fatigue In Patients With Multiple Sclerosis
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Abstract
Multiple sclerosis (MS) is a chronic disease of the central nervous system that leads to various physical and psychological disabilities. Multiple sclerosis patients suffer from many neurological deficits and impairments such as motor disorders, sensory disorders, communication disorders and cognitive deficits. Sleep disturbances are more common in people with MS than in healthy people. causes of poor sleep in MS are likely to be multifactorial and can be related to negative effects of immunotherapy and symptomatic medications as well as other symptoms associated with MS.
Aim of the study: The purpose of the current study was to investigate the relationship between sleep disturbance and fatigue in patients with multiple sclerosis.
METHODS: This is cross sectional study, forty relapsing-remitting MS(RRMS) patients of both sexes were recruited from the outpatient clinic of the Faculty of Physiotherapy as well as the Kasr Al-Aini Multiple Sclerosis Unit (KAMSU) at the Faculty of Medicine, Cairo University. All patients were diagnosed and referred by a neurologist with clinically defined multiple sclerosis according to the revised McDonald’s criteria. The study was applied during a period of remission. Patients were selected according to the following criteria: patient age ranged from 20 to 40 years, patients with EDSS no more than four, and patients who have not had relapses for the previous four months, and patients who have sufficient cognitive abilities to be able to understand and follow instructions with a score greater than 24 according to the Mini Mental State Examination Scale (MMSE).patients were assessed using Fatigue severity scale(FSS) for physical performance, Pittsburgh sleep quality index (PSQI) and Epworth sleepiness scale (ESS) for sleep disorders
Results: There was a significant positive association between the Pittsburgh sleep quality index (PSQI) and the fatigue severity scale (FSS), and there was no association between the Pittsburgh sleep quality index (PSQI) and the Epworth sleepiness scale (ESS) and there was no association between the Epworth score for drowsiness (ESS) and fatigue severity scale (FSS).
Conclusion: it can be concluded that sleep disturbance has a significant impact on physical ability and physical fatigue of patients with multiple sclerosis. It is also important to reveal that there is no relationship between daytime sleepiness and the severity or degree of physical fatigue.