الفهرس 
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Abstract
Many studies were conducted on acute ischemic stroke patients and relation between the severity and outcome of these patients and number of cerebral microbleeds. They revealed that patients with higher numbers of cerebral microbleeds had worse outcomes as the number of CMBs is a marker of small vessel disease and friable blood vessels which is related to more incidence of hemorrhagic complication following intravenous thrombolysis.
The aim of this work was to study the predictors of occurrence of cerebral microbleeds after intravenous thrombolysis in patients with acute ischemic stroke and to clarify their impact on the clinical outcome from thrombolysis.
The present study was conducted on 61 patients diagnosed with acute ischemic stroke in the therapeutic window and treated with intravenous rt-PA with a mean age 63.2 ± 13.02 years.
Severity of stroke of the included patients was assessed by National Institute of Health Stroke Score (NIHSS) on admission, after 24 hours from thrombolysis, after 1 week of the onset of stroke also, follow up of outcome and short-term disability using modified Rankin Scale (mRS).
Infarction size was measured using the pure ellipsoid model of ABC/2.
All patients included in our study had Magnetic Resonance Imaging (MRI) of the Brain with gradient echo (GRE) T2* after 24 hours from the onset of symptoms.
The results of our study were summarized in the following:
1) The mean value for NIHSS at day 1 in the included patient was 9.21 ± 5.79.
2) Complications from rt-PA injection occurred in 21.3% (n=13) of patients whereas 78.7%(n=48) did not have any complications.
3) The mean value of infarction size in the included patients was 33.9 ± 43.18.
4) In the present study, 49.2 (n=30) of patients had Fazekas grade 1, 21.3% (n= 13) had Fazekas grade 2, 19.7% (n=12) had Fazekas grade 0, and 9.8% (n=6) had Fazekas grade 3
5) The mean value of lobar microbleeds in the included patients was 4.7 ±3.05, for infratentorial microbleeds 1.03± 1.64, for deep microbleeds 1.69 ± 1.97 and for total number of microbleeds 7.43 ± 4.58
6) There was a statistically significant positive correlation between age and total number of microbleeds ((r) Coef. = 0.397, P-value =0.002)
7) There was no statistically significant correlation between total number of microbleeds and NIHSS before ((r) Coef. =0.031, P-value= 0.814) and there was no statistically significant correlation between total number of microbleeds and NIHSS 7 days after thrombolysis ((r) Coef. = 0.112, P-value = 0.391)
8) There was a statistically significant positive correlation between MAP at stroke onset and total number of microbleeds ((r) Coef. =0.452, P-value< 0.001)
Conclusion:
• Cerebral microbleeds are more prevalent in older age.
• Cerebral microbleeds are more likely to be present in patients with hypertension.
• Higher number of cerebral microbleeds is not necessarily associated with worse outcome and more hemorragic complications after intravenous thrombolysis.