الفهرس 
Expression and polymorphism of long non-coding RNAs in colorectal cance
ABSTRACTOnly 14 pages are availabe for public view
 |  | from | 154 |  |  |
| | | from | 154 | | |
Abstract
Background: Colorectal cancer (CRC) is a complex disease that develops as a
consequence of both genetic and environmental risk factors. Diet, smoking and
drinking habits are among environmental factors frequently associated with CRC
risk.
Aim of work: The present study aims to conduct a clinical biochemical study that
aids in the investigation of some non-coding RNA expressions and polymorphisms
(including long non-coding RNAs and miRNAs) namely, Plasmacytoma Variant
Translocation-1 (PVT-1) and miR-186 in an attempt to provide new noninvasive
diagnostic biomarkers for CRC of the Egyptian patients.
Patients and methods: Eighty CRC studies and thirty healthy controls were
included. Laboratory and pathological investigations were assessed. Serum miR186 and long non-coding PVT-1 was measured as well as genotype for PVT-1
rs13255292.
Results: The CRC patients had a mean age of 50.9112.0. The mean serum miR186 level in CRC patients (1.380.21) was significantly higher than in the control
(0.930.1) (p=0.0001). The PVT-1 level in CRC patients was (5.910.25)
significantly higher than control (1.10.2) (p=0.001). The PVT-1/ rs13255292
genotype CT was significantly higher compared to the control group. The T allele
was highly significant with a p-value of 0.008 in the CRC patient group with
respect to the control.
Conclusion: miR-186, long noncoding PVT-1 as well as PVT-1 the T allele may
be considered as genetic markers for CRC susceptibility.