الفهرس 
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Abstract
Cisplatin- platinum based chemotherapeutic agent- has been viewed as a cornerstone in the treatment of wide range of human cancers such as ovarian, testicular, bladder cancer, in addition to hematological tumors such as leukemia. Male survivors especially in cases of testicular carcinoma, leukemias and lymphoma suffered from reduced fertility. This raised the need for a new medical field named oncofertility that aims to preserve the gonadal function in patients on cancer therapy.
Recently, herbal medicine has emerged as an essential alternative in treatment of variable medical conditions. In this context, the aim of this study was to investigate the prophylactic role of thymoquinone (Thq) against cisplatin induced testicular injury. It exerts its beneficial effects through its powerful antioxidant, antiapoptotic and anti-inflammatory properties. It is one of the most widely used protective agents owing to its low toxicity in addition to high efficacy.
Despite the beneficial effects of Thq, its oral bioavailability is limited due to its high hydrophobicity, limited absorption and excessive plasma proteins binding. Therefore, implementation of lipid based nanocarriers as nanostructured lipid carriers is essential to improve Thq bioavailability. In the present study, we aimed to assess the protective role of thymoquinone as compared to thymoquinone loaded nanostructured lipid carriers (ThqNLC) to avoid cisplatin induced testicular toxicity in rats.
The animals were randomly allocated in four groups 12 rats each: