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Abstract
Background: chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities, since evidence has showed that a number of different inflammatory cells and mediators play roles in the progression of COPD. The potential importance of IL-6 in the pathogenesis of COPD is suggested by studies showing that high levels of serum IL-6 are associated with impaired or a rapidly declining lung function. Vitamin D deficiency is prevalent among patients with COPD and may play a role in regulation of several genes involved in inflammation, immunity, cellular proliferation, differentiation, and apoptosis. Aim of work: To measure serum level of interleukin 6 and vitamin D in stable COPD patients, and their relation to COPD severity and to determine if there is a relationship between vitamin D and interleukin 6 in COPD patients. Methods: The study included 70 individuals; they were divided into two groups. The first group included 50 patients who were diagnosed as COPD patients using post bronchodilator spirometry; the second group included 20 healthy individuals. All patients were subjected for the following: Complete history taking and clinical examination, spirometry, 6 minute walk test and oxygen saturation assessment by pulse oximtery and measuring of serum level of vitamin D and interleukin 6. Results: The result of the study revealed that there is increase in serum level of interleukin 6 and defiency of serum level of vitamin D in COPD patients comparing to normal individuals and there was significant correlation between serum level of vitamin D and COPD severity. Conclusion: There is increase in serum level of interleukin 6 and defiency of serum level of vitamin D in COPD patients with evidence of relationship between vitamin D and FEV1