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Abstract
Bee venom has been used in treatment of many inflammatory diseases, some autoimmune diseases and bovine mastitis. There are some commercially available drugs prepared from bee venom that are used for medical purposes. Abevac is one of these bee venom drugs. The present study showed the effect of Abevac against some reference strains of pathogenic gram-positive, gram-negative bacteria and C. albicans fungus (S. aureus, S. pyogenes, B. cereus, P. multocida, S. entritidis, E. coli, M. synoviae, M. gallisepticum, M. bovis and C. albicans) through measuring zone of inhibiton and determination of MIC and MBC of bee venom in comparison with 14 different members of antimicrobial agents including penicillin and 4 antifungal agents. The results proved that Abevac had powerful antimicrobial activity against both Gram-positive and gram-negative bacteria and it exhibited significant antimicrobial activity against S. aureus, S. pyogenes, B. cereus, S. entritidis, E. coli and C. albicans while showed no effect on P. multocida, M. bovis and M. synoviae. The present study proved that Abevac had antibacterial efficacy nearly the same of ciprofloxacin drug against the three Gram-positive bacteria