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Abstract
Background: Breast cancer is one of the most common cancers in the world and is the first cause of death due to cancer among women. Mammography is the best screening method and mammographic density, which determines the percentage of fibro glandular tissue of breast, is one of the strongest risk factors of breast cancer. Objectives: The aim of this study was to assess the relation between mammographic density of the breast and breast cancer in Egyptian women. Patients and method: The study included 48,407 women outreached for screening by digital mammography by The Egyptian national breast cancer screening program from January 2011 to December 2014.Their age ranged between 40 and 65. Women were categorized into four groups based on the ACR guidelines: Class A, almost entirely fatty; Class B, scattered fibroglandular tissue; class C, heterogeneously dense; and class D, extremely dense. Results: 561 cases of breast cancer were depicted radiologically and histo-pathologically diagnosed. The frequency of breast cancer among each group was as follows: Class D: 2.31%, Class C: 1.62%, Class B: 1.09%, Class A: 0.72% ”we found statistically highly significant increased frequency of positive carcinoma cases in ACR class B in comparison to class A and the same occurred between each of the two groups. There was a significant increase risk of breast cancer with high densities collectively: ACR-C and ACR-D. Conclusion: The results of our study show that in Egypt, an increase in the mammographic density is associated with an increase in frequency and risk of breasr cancer