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Abstract Crosslinked poly(vinyl alcohol) (PVA) and poly(ethylene glycol) (PEG)/Carboxymethyl chitosan (CMCh) nanocomposites were synthesized using terephthaloyl diisothiocyanate crosslinker, in the presence of montmorillonite (MMT), in different ratios of the two systems. characterization of nanocomposites was performed using different spectral analyses. Swelling behavior was studied in different buffered solutions. It was found that formation of crosslinked CMCh/PVA and CMCh/PEG hydrogels increased the swell ability. Metal ions adsorption has also been investigated. The results indicated that crosslinked CMCh/PVA and CMCh/PEG nanocomposites adsorbed various metal ions much more than non crosslinked CMCh. Antimicrobial activity was examined against Gram-positive bacteria, Gram-negative bacteria, and also against fungi. Results indicated that most of these nanocomposites exhibited good antimicrobial potency. Degradation study was carried out in Simulated Body Fluid (SBF) for different time periods in order to find out the degradation index (Di). Results showed that weight loss of most of the nanocomposites increased as a function of incubation time |