الفهرس | Only 14 pages are availabe for public view |
Abstract Background: Diabetes mellitus (DM) is considered one of the largest emerging threats to health in the 21st century. Diabetic patients have a higher risk of infections which is the leading trigger of diabetic ketoacidosis. The second most common infection in diabetics is urinary tract infection (UTI). Elevation of glucose level induces an inflammatory process within numerous tissues in the body leading to disturbance in cytokines level and oxidative stress. Objective: This study is divided into two parts, firstly it was to investigate the prevalence of asymptomatic bacteriuria (ASB) and urinary tract infections, the second part is to determine the level of IL- 1Ý, IL-6 and superoxide dismutase (SOD) in blood samples of diabetic and ketoacidotic patients. Methods: Urine samples were collected to examine the prevalence of asymptomatic bacteriuria (ASB) in 84 Type 1 diabetes patients, 63 Type 2 diabetes patients and 57 ketoacidotic patients, and to determine the uropathogens responsible for ASB and UTIs as well as their Abstract xvi antimicrobial susceptibility pattern. Blood samples were collected from diabetic patients, ketoacidotic patients and control group for examination of IL-1Ý, IL-6 and superoxide dismutase. |