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Abstract Background: Immune thrombocytopenia is the most commonly acquired bleeding disorder in children. About 65{u2013}80% of new-onset immune thrombocytopenia children undergo spontaneous recovery within 1 year. Purpose: To compare the efficacy and safety of different treatment options for acute immune thrombocytopenia in pediatrics, in increasing the platelet count, decreasing the severity, frequency or cessation of bleeding. Patients and Methods: Retrospectively, all patients who presented to the pediatric hematology clinic, Cairo university children hospital, with the clinical and laboratory diagnostic features for acute immune thrombocytopenia, during the period from from 1st of January 2014 to 1st of January 2015 were included. All clinical and epidemiological data were abstracted from the medical records. Results: A total of 57 males (55.9%) and 45 females (44.1%) mostly presented with cutaneous bleeding. ITP diagnosis was preceded by upper respiratory tract infection (URTI) which was found in 11 patients (11%). Treatment regimens varied between glucocorticoids (oral or intravenous), IVIG and observation. A total number of 42 patients (41.17%) were counted as lost follow up at the 6th month. Most of them were in complete response. Males showed more response than females at both 3rd month p=0.231 and 6th month p=0.043 |