الفهرس 
Gainful Role of Fennel Oil on Development of Albino Rat Neonates Post Topiramate Administration
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Abstract
Topiramate (C12H21NO8S) is a sulfamate substituted monosaccharide that is a novel antiepileptic agent. In 1996, the Food and Drug Administration approved it for partial seizures in adults. Chemically, it is known as 2, 3:4, 5 bis-o (1 methyl ethylene) – b-D- fructopyranose sulfamate. This medication reduces voltage-gated Na+ current in cerebellar granule cells by acting on the channel’s inactivated state. It inhibits carbonic anhydrase weakly, increases postsynaptic GABA receptor currents, and limits glutamate receptor activation of the AMPA and Kainate subtypes. The effect of fennel oil on topiramate toxicity in albino rat neonates was investigated in this study. The nursing mothers were separated into four groups: group 1 the control (negative), group 2 the control (positive) were given fennel oil (1ml/kg) orally, group 3 Treated administrated with dose equivalent to the human dose (100mg/kg ) topiramate and group 4 Co-Treated administrated with (100mg/kg ) topiramate and (1ml/kg) fennel oil from a day of 1st till 21st day of lactation, At the 7th, 14th, and 21st days of nursing, albino rat neonates were slaughtered under anaesthesia, the organs were extracted (liver, kidney, brain) for histological analysis, and the bones were dyed for morphological assessment. the result showed a decrease in body weight and height of albino rat neonates from the treated group than from co-treated one. Also, there is a histopathological change of examined tissues neonates which is treated with topiramate, the fennel oil administration after topiramate intake enhanced the decreasing of neonatal body weight & ameliorated the alternation of tissues histology. The skeletal system show no abnormalities and the skeletal bone are well ossified in all groups, therefor the fennel oil is considered to be given with topiramate during the lactation period.