الفهرس 
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Abstract
One of the leading 10 causes of death is trauma. Critically ill and trauma patients present unique challenges for resuscitation. Verification of the various measurements is done using clinical and laboratory parameters. The ideal marker or score should be accessible, affordable, and demonstrate adequate resuscitation in a short period of time. Numerous researches have examined lactate clearance at 6- and 12-hour intervals. The initial spike in lactate levels is known to subside over time.
However, the trauma surgeon requires a quick, objective measure of his resuscitation efforts. To determine if initial blood lactate and non-normalization of lactate might predict mortality in trauma and to contrast these with the trauma-specific scores, including the revised trauma score (RTS), injury severity score (ISS), and trauma-related injury severity score (TRISS).
The aim the current study is to evaluate the significance of initial lactate and delta lactate in the first 24 hours in trauma patients, to study the following outcomes:
The primary outcome is the non-normalization of lactate in the first 24 hours is a risk factor of in hospital mortality or not?
The ability of non-normalization of lactate in the first 24 hours to predict the following secondary outcomes:
• Prediction of other clinically relevant endpoints.
• The risk factors for patients not to have lactate normalization in the 24 first hours.
• Correlation of initial blood lactate and its variations (delta lactate) on outcomes and trauma scores: Trauma Injury Severity Score (TRISS), Mechanism, Glasgow coma score, Arterial Pressure (MGAP), Simplified Index of Gravity Score (IGS II), sequential organ failure assessment score (SOFA) and injury severity score (ISS).
This monocenter observational study was conducted in a French academic trauma center (corresponding to a level-1 trauma center). Data were collected prospectively from a trauma registry used in Hôpital Nord, Marseille. This registry (Traumabase®, traumabase.eu) is shared between 16 trauma centers in France.