الفهرس 
Anatomy and DevelopmentOnly 14 pages are availabe for public view
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Abstract
Introduction: Diabetes mellitus is a chronic metabolic disease with a wellknown gastrointestinal complication. Oxymatrine is a Chinese medicinal plant with many pharmacological activities, including anti-oxidant, antiinflammatory and anti-apoptotic effects. Aim of the work: This work was performed to evaluate the histological effect of diabetes on the jejunum of adult male albino rat and the possible protective role of oxymatrine. Materials and Methods: Fifty-five adult male albino rats were divided into three groups: group I included 15 rats served as control, group II included 10 rats that were given oxymatrine at a dose 100 mg/kg/day orally for 10 weeks and group III included 30 rats that were given a single dose of streptozotocin 50 mg/kg intraperitoneally for induction of diabetes. Then diabetic rats were subdivided into two subgroups: subgroup IIIa didn’t receive any additional treatment and subgroup IIIb received oxymatrine at a dose, route and duration similar to that of group II. Results: The diabetic group showed disturbed villi architecture with sub epithelial spaces and desquamated epithelial surfaces. Moreover, areas of hemorrhage and cellular infiltration of lamina propria were detected. Transmission electron microscopy revealed enterocytes with short and focal loss of microvilli. Destroyed mitochondria, dilated rER, cytoplasmic vacuoles and lipid droplets were also detected. Moreover, shrunken nuclei with irregular outlines were demonstrated. Most of these histological alternations were less pronounced in diabetic rats that received oxymatrine. Conclusion: oxymatrine can protect the jejunum against changes induced by diabetes through its anti-oxidant, anti-inflammatory and anti-apoptotic effects.Introduction: Diabetes mellitus is a chronic metabolic disease with a wellknown gastrointestinal complication. Oxymatrine is a Chinese medicinal plant with many pharmacological activities, including anti-oxidant, antiinflammatory and anti-apoptotic effects. Aim of the work: This work was performed to evaluate the histological effect of diabetes on the jejunum of adult male albino rat and the possible protective role of oxymatrine. Materials and Methods: Fifty-five adult male albino rats were divided into three groups: group I included 15 rats served as control, group II included 10 rats that were given oxymatrine at a dose 100 mg/kg/day orally for 10 weeks and group III included 30 rats that were given a single dose of streptozotocin 50 mg/kg intraperitoneally for induction of diabetes. Then diabetic rats were subdivided into two subgroups: subgroup IIIa didn’t receive any additional treatment and subgroup IIIb received oxymatrine at a dose, route and duration similar to that of group II. Results: The diabetic group showed disturbed villi architecture with sub epithelial spaces and desquamated epithelial surfaces. Moreover, areas of hemorrhage and cellular infiltration of lamina propria were detected. Transmission electron microscopy revealed enterocytes with short and focal loss of microvilli. Destroyed mitochondria, dilated rER, cytoplasmic vacuoles and lipid droplets were also detected. Moreover, shrunken nuclei with irregular outlines were demonstrated. Most of these histological alternations were less pronounced in diabetic rats that received oxymatrine. Conclusion: oxymatrine can protect the jejunum against changes induced by diabetes through its anti-oxidant, anti-inflammatory and anti-apoptotic effects.