الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 120 |  |  |
| | | from | 120 | | |
Abstract
Cataract extraction by phacoemulsification is the most frequently performed ophthalmic surgery around the world, in which an ultrasonic device vibrating at a very high speed is inserted into the eye through a very small corneal incision, and today it focuses on rapid visual rehabilitation after surgery. Endothelial cell loss after cataract surgery is an inevitable consequence of the procedure.
This descriptive prospective study was carried out to assess the influence of uneventful phacoemulsification on the corneal endothelium one- and three-months post-operative in 30 Eyes by specular microscopy in moderately hard N3 cataract graded by oculus PNS for patients attending the specialist eye hospital at EL- Menoufia. A total of 30 eyes of 30 patients were enrolled in our study of both gender with age-related nuclear cataracts without previous history of ocular surgery.
Including; patients complaining of diminution of vision of gradual onset and progressive course, adult patients from 50 to 70 years of age, both gender with no prior ocular disease, crystalline clear cornea devoided from any corneal dystrophy and degenerations, moderately hard senile cataract according to LOCS classification, undergoing routine phacoemulsification surgery using horizontal, corneal endothelial cell density more than 1500 cell/mm.
Excluding; patients with evidence of proliferative diabetic retinopathy (T2DM group) characterized by the occurrence of vitreous hemorrhage or tractional retinal detachment, local eye disease and previous surgery, preoperative endothelial count less than 1500 cells/mm, any type of corneal pathology as corneal degeneration and
Summary
89
corneal dystrophy, contact lens wear history, ocular trauma or surgery, current use of any kind of ocular treatment other than eye lubricant, and patients with conditions that would prevent evaluation of the cornea by specular microscopy.
All patients underwent a complete baseline ophthalmological examination, full medical and ophthalmic history, clinical examination including BCVA, slit-lamp examination, fundus examination by slit-lamp bio microscopy using 78D lens, IOP.
The specular microscopy examination was performed before surgery, at the 1st and 3rd month follow-up visits after the phacoemulsification procedure.
Our study results have revealed that the mean age of the studied sample is (59.53 ± 6.334 years) ranged from 50 to 73 years. The majority of patients 20 (66.7%) were males, while only 33.3% (10) were females.
The mean number one week after PHACO (189.67 ± 61.823) (p=0.004), one month after PHACO (164.73 ± 51.228) (p˂ 0.001), and three months after PHACO (167.87 ± 46.919) (p˂ 0.001), were statistically significantly lower than the mean number before PHACO (189.67 ± 61.823).
The mean CD one week after PHACO (2135.5 ± 416.41) (p˂ 0.001), one month after PHACO (2095.8 ± 372.33) (p˂ 0.001)., and three months after PHACO (2075.4 ± 282.17) (p˂ 0.001), were statistically significantly lower than the mean CD before PHACO (2439.7 ± 377.51).
The mean HEX one week after PHACO (37.87 ± 4.462) (p˂ 0.001), one month after PHACO (40.97 ± 5.149) (p˂ 0.001), and three
Summary
90
months after PHACO (41.20 ± 5.034) (p˂ 0.001), were statistically significantly lower than the mean HEX before PHACO (49.83 ± 2.019).
The mean AVG one month after PHACO (520.07 ± 126.966) (p= 0.046), and three months after PHACO (512.67 ± 88.310) (p=0.022), were statistically significantly higher than the mean AVG before PHACO (460.00 ± 63.087).
The mean SD one month after PHACO (224.60 ± 60.808) (p= 0.036) and three months after PHACO (222.47 ± 42.265) (p=0.025), were statistically significantly higher than the mean SD before PHACO (187.50 ± 63.511).
The mean CV one week after PHACO (44.63 ± 4.810) (p˂ 0.001), one month after PHACO (43.50 ± 4.740) (p=0.030), and three months after PHACO (43.43 ± 4.584) (p=0.035), were statistically significantly higher than the mean CV before PHACO (41.70 ± 5.234).
The mean CCT one week after PHACO (526.77 ± 55.535) (p˂ 0.001), one month after PHACO (531.40 ± 50.736) (p˂ 0.001), and three months after PHACO (546.37 ± 34.630) (p˂ 0.001), were statistically significantly higher than the mean CCT before PHACO (485.80 ± 63.393).
CD change and Hex change were found to be significantly negatively correlated with CD before PHACO (r=-0.600; p˂ 0.001, r=-0.578; p=0.001 respectively). CD change and Hex change were found to be significantly negatively correlated with Hex before PHACO (r=-0.670; p˂ 0.001, r=-0.767; p˂ 0.001 respectively). AVG change and SD change were found to be significantly negatively
Summary
91
correlated with AVG before PHACO (r=-0.704; p˂ 0.001, r=-0.609; p˂ 0.001 respectively).
CD change, Hex change, and CCT change were found to be significantly positively correlated with SD before PHACO (r= 0.683; p˂ 0.001, r =0.837; p˂ 0.001, r =0.528; p= 0.003 respectively), while SD change was significantly negatively correlated with it (r = -0.590; p= 0.001). CV change was found to be significantly negatively correlated with CV before PHACO (r= - 0.605; p˂ 0.001). AVG change and SD change were found to be significantly positively correlated with CCT before PHACO (r= 0.430; p=0.018, r =0.673; p˂ 0.001 respectively), while CCT change was significantly negatively correlated with it (r = -0.869; p˂ 0.001).