الفهرس 
Immunohistochemical evaluation of 2EGFR3 expression in bronchogenic carcinomas
ABSTRACTOnly 14 pages are availabe for public view
 |  | from | 141 |  |  |
| | | from | 141 | | |
Abstract
Purpose : Evaluation of epidermal growth factor receptor (EGFR) immunohistochemical expression in different bronchogenic carcinomas and correlation of EGFR expression with various clinico-pathological parameters. Methods: Immunohistochemical staining for EGFR was performed on paraffin-embedded sections of 40 cases of bronchogenic carcinoma that underwent bronchoscopy (26 cases), computed tomography-guided biopsy (6 cases) or surgery (8 cases), from archive of Pathology department, Kasr AL-Ainy, faculty of medicine, Cairo University in the period from April 2015 to April 2017. Expression of EGFR in >10% of tumor cells was described as positive (over expression). Results: History of smoking showed significant correlation (p value: 0.001) with histological type; where most squamous cell carcinoma (SCC) & half of small cell lung carcinoma (SCLC) cases were smokers. EGFR over expression was detected in 21 cases (52.5%) of bronchogenic carcinoma and distributed as 12/15 (80%) of SCC, 9/17 (53%) of adenocarcinoma (ADC), while all SCLC cases showed negative expression with statistically significant difference (p value= 0.001). There was a significant association between EGFR expression and the sex of ADC cases (p value= 0.027) and history of smoking among ADC cases (p value= 0.001). However there was no significant correlation between EGFR expression and either age or histological differentiation of ADC cases. Also no significant association was detected between EGFR expression and age, sex, history of smoking and histological differentiation in SCC