الفهرس 
Evaluation of survivin expression in squamous cell carcinoma of the larynx :Histopathological and immunohistochemical study
CONTENTSOnly 14 pages are availabe for public view
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Abstract
Survivin is an inhibitor of apoptosis (IAP), is normally expressed in developing tissues, but not in normally differentiated tissues. Unlike other IAPs, survivin is small and has only a single N-terminal baculovirus inhibitor of apoptosis repeat domain, a long C-terminal alpha-helix coiled region, and forms a stable dimmer in solution. It is overexpression is correlated with poor prognosis of malignant tumors and is highly up-regulated in squamous cell carcinoma of the larynx.Aim of work: The aim of this study is to evaluate survivin expression in squamous cell carcinoma of the larynx and to correlate survivin immunohistochemical expression with available clinicopathological data. Methods: 40 total laryngectomy specimens; collected from the Pathology Department, Faculty of Medicine, Cairo University. Two slides were prepared from each paraffin embedded tumor block, one slide for Hematoxylin and eosin staining and the other for immunohistochemically staining by survivin monoclonal antibody. Results: 25(62.5%) cases showed positive survivin expression, which were more associated with tumor mean size, grade, (T) staging and lymph node metastasis with no statistically significant correlation. Significant correlations were found between the following variables, transglottic site with (T4), between (T) staging with tumor size and between grade of the tumor with lymph node metastasis