الفهرس 
Genetic variations in dna repair genes (XRCC1, 3 & 7) and the susceptibility to hepatocellular carcinoma in a cohort of Egyptian patients
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Abstract
Background : DNA repair systems have been considered to maintain genomic integrity by countering threats posed by DNA lesions. Deficiency in the DNA repair pathways might make these lesions unrepaired or repaired incorrectly, eventually leading to genome instability or mutations which may contribute directly to cancer. Thus, genetic differences, such as single nucleotide polymorphism (SNP) may contribute to carcinogenesis. Therefore, great interests have been aroused in the exploration of the association of SNP of DNA repair proteins and cancer risk to provide better prediction of cancer.Aim of the work: The aim of the present study is to assess the association between SNPs XRCC1 G28152A (rs25487), XRCC3 C18067T (rs861539) & XRCC7 G6721T (rs7003908) genes and the risk for HCC in a cohort of Egyptians. Subjects and Methods: The study was conducted on 260 subjects classified into three groups: HCC group included 100 patients; a control group of 100 age and sex matched healthy volunteers, and HCV positive HCC negative group including 60 patients.Genotyping of XRCC1, 3&7 genes was performed by Real time PCR. Results: XRCC1 G28152A (rs25487) heteromutant genotype (GA) was significantly higher in HCC patients than controls (57 % vs 36%) and conferred almost 3 fold increases of risk of HCC (OR==2.735, 95%CI= 1.504-4.97, p value = 0.001),while the homomutant genotype (AA) was higher in HCC patients than controls (10% vs 7%), but the difference was statistically non-significant (p value =0.094). The frequency of XRCC3 C18067T (rs861539) variant genotypes were close to that of the controls and the difference was statistically non-significant (p value = 0.24, 0.37 for the CT, TT respectively)