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العنوان
Analytical study of some drugs affecting the central nervous system /
الناشر
Abeer Rashad Abdel Moneim Derar ,
المؤلف
Abeer Rashad Abdel Moneim Derar
هيئة الاعداد
باحث / Abeer Rashad Abdel Moneim Derar
مشرف / Azza Aziz Mohamed Moustafa
مشرف / Nesrin Khamis Ramadan Selim
مشرف / Taghreed Abdel Fattah Mohammed
تاريخ النشر
2018
عدد الصفحات
285 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Analytical Chemistry
تاريخ الإجازة
10/10/2018
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Analytical Chemistry
الفهرس
Only 14 pages are availabe for public view

from 375

from 375

Abstract

This thesis deals with an analytical study of some drugs that acts on the central nervous system receptors, namely, dapoxetine hydrochloride, tadalafil, donepezil hydrochloride and memantine hydrochloride.The aim of this work is to develop different analytical methods which are characterized by simplicity, accuracy and appropriate degree of sensitivity for the analysis of the studied drugs in their powdered form, laboratory prepared mixtures and in their pharmaceutical dosage form.This thesis contains four parts in addition to the references and summaries in Arabic and English; Part I: General introduction and literature review Part II: Electrochemical methods for determination of dapoxetine hydrochloride and Donepezil hydrochloride as ion selective electrodes, conductometric titration and voltammetric methods.Part III: chromatographic methods for simultaneous determination of dapoxetine hydrochloride / tadalafil and donepezil hydrochloride / memantine by thin layer chromatographic-spectrodensitometric,high performance liquid chromatographic methods and gas chromatography in pure form and in pharmaceutical formulation. Part VI: Spectrophotometric methods for simultaneous determination of dapoxetine hydrochloride / tadalafil in pure form and in pharmaceutical formulation.This thesis also contains 60 tables, 66figures and 272 references