الفهرس 
Effect of aerobic exercises onimmune system in patients with multiple sclerosis
ABSTRACTOnly 14 pages are availabe for public view
 |  | from | 170 |  |  |
| | | from | 170 | | |
Abstract
Background: The immune pathogenesis is one of the hallmark of multiple sclerosis. Aerobic exercises may affect the immune regulation in MS patients. The aim of this study is to determine the effect of aerobic exercises on the immune system anti inflammatory (IL-10) and pro inflammatory (IL-17) cytokines and its consequences on the functional status in the Multiple Sclerosis patients. Methods: Thirty male & females MS patients and fifteen normal matched subjects to detect normal references range values of IL-10 & IL-17 represented the sample of the study. Their age ranged from 25 to 45 years. The patients were assigned into two equal groups; study group (GA) and control group (GB) in addition to normal subjects (GC). GA treated by the disease modifying drug (interferon beta-1a) ”Rebif” in addition to a physical therapy program of aerobic exercises conducted two times per week for eight weeks for 40 min. GB treated by the same disease modifying drug only. Pre and post assessment were done by measurement of the immune parameters through measurement of serum IL-10 & IL-17 by ELISA test .The functional status and severity of the disease were assessed by expanded disability status scale (EDSS). Results: There was a significant increase of anti inflammatory (IL-10) cytokine as well as significant decrease of pro inflammatory (IL-17) cytokine and EDSS in the study group compared to the control group (P<0.05). Conclusion: Aerobic exercises has a positive effect on the immune system and consequently improving functional status in MS patients