الفهرس 
Bone density in pediatric patients on regular hemodialysis and post renal transplantation
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Abstract
Background: Successful kidney transplantation and proper regular hemodialysis corrects many of the metabolic abnormalities associated with development of renal osteodystrophy, but despite a wellfunctioning graft and efficient dialysis, osteopenia and osteoprosis, remains prevalent in adult and pediatric kidney recipients and patients on regular hemodialysis, The factors that affect the bone mineral density (BMD) and the long term course of BMD after transplantation and regular hemodialysis in children is still not been adequately studied. Methods& Results: We performed a cross sectional study to determine BMD in 60 patients group } will be 30 children with ESRD on regular hemodialysis HD; group S will be 30 children with post renal transplant TX in in Nephrology Unit, Cairo University Children{u2019}s Hospital by dual energy x-ray absorptiometry at various time intervals after transplantation and hemodialysis (mean duration after transplantation was 4.047 ± 1.92 years, and 4.81±3.49 years in hemoldilysis ). The mean ± SD for BMD was -2.127± 1.64 and -2.48± 2.09 for lumbar 2-4 spine in renal TX & HD group respectively corrected for body surface area. Osteopenia/osteoporosis were present in about two thirds of patients. The signi{uFB01}cant risk factors for osteopenia/osteoporosis using univariate analysis was the cumulative dose of steroids/m2 surface area, graft dysfunction in TX group &may be the duration in HD group.Conclusion: osteopenia and osteoporosis are common in pediatric renal transplant patients. The cumulative steroid dose was the major predictor for bone loss &increase risk of fracture even without evident clinical manifestation to fractures