الفهرس 
Role of tissue (CD8, CD45RO, and FOXP3) in non segmental vitiligo as possible factors in pathogenesis and disease activity /
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Abstract
Background: Vitiligo is a common disfiguring disorder which may have devastating psychological and social consequences. The exact etiology of vitiligo remains obscure. Studies have indicated a role for cellular immunity in the pathogenesis of vililigo and how it affects the stability of the disease and its implication on the outcome of vitiligo treatment. Objective: To assess tissue CD8+T cells, CD45RO+cells, as well as FoxP3 in perilesional skin in both active and stable non segmental vitiligo cases as well as normal healthy controls, aiming to verify the immunological mechanism for melanocytic destruction in such disease and also to assess the stability of the disease to facilitate better patient selection for melanocyte transplantation. Methods: This study included forty patients with non-segmental vitiligo lesions (20 active and 20 stable), as well as twenty tissues samples of normal healthy controls. A 3mm punch biopsy was taken from the margin of vitiligo lesions and from normal control group. Immunohistochemical staining was done for the expression of CD8+T cells, CD45RO+ and FOXP3+cells in all cases and controls. Minipunch graft was done for most NSV patients and after 3-6 months, the patients were reassessed for repigmentation. This was enterpreted as follow: Good response had spread of pigment >1 mm and poor response had no spread of pigment or loss of color